This study investigated the frequency of consanguinity among
parents of newborns with inborn errors metabolism (IRM), and integrated these
data with medical records of parents on consanguinity in Denmark. The data
were obtained through national screening program of newborns over a period of
15 years. 196 newborns appeared to have an IEM of whom 155 from Denmark were included in the analysis. The medical records revealed that among ethnic Danes only two
cases of consanguinity were identified among 93 families versus 20 cases
identified among ethnic minority (Pakistani, Afghan, Turkish and Arab origin) suggesting
a higher rate of consanguinity among these minorities. The integration of both
data showed that the frequency of IEM was 25.5 times higher among children from
ethnic minority compared to Danes, which indicates a strong positive correlation between
consanguinity and the risk of inborn errors of metabolism.
Sylvain
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