It is generally known that mRNA translation is a crucial
phase in proteins synthesis. However, the impairment in this process has been
linked to multiple neurological disorders.
This review published last month in Trends in Genetics gives insight into the role of tRNAs and ribosomes
in the accurate and precise translation and addresses some neurological disorders
associated to errors that occur in the
process of translating mRNA.
As you know, translation of mRNA is the next step
after DNA transcription and it is facilitated by ribosomes that translate the
genetic information contained in the mRNA. In this process tRNAs play a major
role where they bind the appropriate amino acids(aminoacylation of tRNAs) and
carry them to the ribosome where they find the matching three-nucleotides
sequences in a mRNA for the production of polypeptide. However, it happens that
some errors occur in the process which may lead to some abnomarlities. As an
example, authors of this review indicate how mutations in the enzymes that
catalyze the tRNA aminoacylation may results to neurological disorders
including epilepsy. They also mention how mutations in ribosomal proteins may
be linked to disorders such as anemia and abnormalities in cranial facial
development. In addition, errors in translation elongation phase have shown to
result in the production of proteins with reduced or abnormal function which in
turn has been associated to neurodegeneration and motor dysfunction effects.
Given different
findings discussed in this paper it appears that neurons are sensitive to the
impaired mRNA translation and the current paper highlights the importance of
translation fidelity.
Here below
is the link for the paper:
https://ac.els-cdn.com/S0168952517302275/1-s2.0-S0168952517302275-main.pdf?_tid=8a50f71d-603a-469a-ad02-eb625c3dfb8f&acdnat=1523929568_537e143f5594231f945feeee99725335
Axelle
Second non-potluck post
publication from Trends in Genetics
journal
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