This study suggests that certain epigenetic factors and
consumption of alcohol which have been previously found to suppress DNA
methylation may influence the development and progression of epithelial ovarian
cancer. They however note that there is no clear understanding whether these
factors interact to affect the EOC risk. They performed a causal inference test
(CIT) and the VanderWeele and Vansteelandt multiple mediator model to examine
CpG sites that mediate the association between alcohol consumption and EOC
risk. They
found that decreased methylation at both CpGs was more common in cases who
drank alcohol at the time of enrollment vs. those who did not.
Link: here
Joanne
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