This is the blog for GW students taking Human Evolutionary Genetics. This site is for posting interesting tidbits on: the patterns and processes of human genetic variation;human origins and migration; molecular adaptations to environment, lifestyle and disease; ancient and forensic DNA analyses; and genealogical reconstructions.

GWHEG figure

GWHEG figure

Friday, April 27, 2018

Journal update 2/3: Alcohol consumption may influence the development and progression of epithelial ovarian cancer.


This study suggests that certain epigenetic factors and consumption of alcohol which have been previously found to suppress DNA methylation may influence the development and progression of epithelial ovarian cancer. They however note that there is no clear understanding whether these factors interact to affect the EOC risk. They performed a causal inference test (CIT) and the VanderWeele and Vansteelandt multiple mediator model to examine CpG sites that mediate the association between alcohol consumption and EOC risk. They found that decreased methylation at both CpGs was more common in cases who drank alcohol at the time of enrollment vs. those who did not.

Link: here

Joanne

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