This paper represents the first gene-level analysis of GWAS data for systemic sclerosis. The goal of the paper was to analyze genetic susceptibility loci in systemic sclerosis at the gene level in order to determine if associations were shared in African American and White populations. In both racial groups, analysis integrated association statistics in a gene possibly containing multiple SNPs with "weak effect on disease risk." 4 genes were found to significantly associate with systemic sclerosis in Whites, but only one of these candidate genes was found to be significantly associated in African-Americans. The authors acknowledge that the sample size disparity in their study between Whites and African Americans was a problem, which calls out the need for this study to be replicated in order to validate the results.
Article here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189498#
Third post from PLoS ONE
Kim Foecke
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