Journal Update 3: Circadian transcription of the genome

Y. H. Kim et al., Rev-verbα dynamically modulates chromatin looping control circadian gene transcription. Science 359, 1274-1277 (2018).

Circadian plasticity of chomatin folding
(Lima & Göndör, 2018)

In the March 16th 2018 edition of Science, Kim et al. published their work detailing the circadian plasticity of gene regulation. The circadian clock determines the 24 hour cycle by which metabolic and physiological processes adhere to. Specifically, Kim et al. discuss the role of protein  Rev-erbα in the circadian rhythm of chromatin folding, an important process that affects gene expression during the phase of transcription. The authors found that the circadian chromatin plasticity is restricted to only specific regions of genes, their results also lend support to the hypothesis that there is interaction between metabolic processes and genes.

Click here for the full paper.

- Angie

Journal Post 3/3