Depression is a common psychiatric disorder that has been
linked to both genetic and environmental factors. It is important to identify potentially
positive biomarkers for depression that can facilitate detection at an early
stage. Previous studies have
shown that the detailed
etiology of depression remains unclear and there seems to be no validated biomarkers despite the numerous genetic and epigenetic studies that have
been performed. In this specific study
scientists set out to investigate whether different levels of DNA methylation
were associated with depressive tendencies. They performed an epigenome-wide
association study (EWAS) of DNA methylation on subjects with or without depressive
symptoms. They found that G-protein coupled receptor protein signaling pathways
are involved in the pathogenesis of depression. This study however needs
further research and validation by using a bigger sample size than the one used
in this study.
Link: here
Joanne
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