Non Putluck Post- Carly Johnson #3

Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species

Mammals have a wide and varied lifespan, but recent studies have established ageing- associated differently methylated positions in human and mouse.  After studying mammals such as a mouse, human and whale that vary greatly in size and lifespan and determining an association, they tested the theory on dogs, in which this is not the case. In all, this study identified six negative relationships between rate of change of methylation levels a DMPs and lifespans, this study is hopeful that aDMPS will be a sound molecular tool for out future understanding of the biological factors that determine lifespan in mammals.

Robert Lowe^†Email author,

Carl Barton^†,

Christopher A. Jenkins,

Christina Ernst 

Oliver Forman,

Denise S. Fernandez-Twinn, 

Christoph Bock, 

Stephen J. Rossiter, 

Chris G. Faulkes,

Susan E. Ozanne,

Lutz Walter,

Duncan T. Odom,

 Cathryn Mellersh and

 Vardhman K. RakyanEmail author

^†Contributed equally

Genome Biology201819:22

https://doi.org/10.1186/s13059-018-1397-1

©  The Author(s). 2018

Received: 27 September 2017

Accepted: 19 January 2018

Published: 16 February 2018