We didn't get into epigenetics much this semester, but a recent AJPA article on the topic caught my attention. The authors investigated ten genes related to DNA methylation/demethylation in the context of stress and overall health. 25 mother-infant dyads from Goma, DRC were studied. Genetic and epigenetic data were combined with surveys and interviews on perinatal stress. Stressors included everything from in-law stress to war trauma. Results indicated that most genes in question did not affect genome-wide methylation or birthweight. However, DNMT1, DNMT3A, TET3, and MBD2 were found to correlate with maternal methylation and birthweight. The authors suggest that these genes may be part of a molecular mechanism underlying the human biological response to stress.Read the full article here.
(AJPA post 2/3)
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