Non-potluck post from The American Journal of Human Genetics: Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans

Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans

In this paper, the authors demonstrate how different populations living in similar condition can adapt to high altitude through different pathways. Unlike Tibetan highlanders adapted to high altitude via the selection of genetic variants associated with reduced polycythemic response to hypoxia, this study shows that Andeans adapt to high altitude through other mechanisms. A whole-genome sequencing showed the strongest evidence of selection of BRINP3, NOS2, and TBX5, which were also associated with cardiovascular development and function, but not in response to hypoxia. Using the association mapping, they found that this selection might be associated with phenotypic variations related to cardiovascular health.

Link: https://ac.els-cdn.com/S0002929717303920/1-s2.0-S0002929717303920-main.pdf?_tid=2a89962e-99ee-42ac-96e4-d5bc7e0959f2&acdnat=1523637897_dc1856f70497ed7bb5830e47312b1754

_Sylvain

First post from The American Journal of Human Genetics