Adrian et al. examine a family of receptor molecules, known as CEACAM, which enable bacterial pathogenic colonization. A particular phagocytic receptor, CEACAM3, can attack bacterial pathogens and has been shown to be under strong positive selection, with a high number of nonsynonymous mutations compared to synonymous mutations. Their research suggests that this family of innate immune receptors appeared after Old World monkeys split from other primates. Within the human lineage, CEACAM3 has developed mutations that allow it to detect and bind species-specific human restricted bacteria. Furthermore, different populations around the world are shown to have varying degrees of polymorphisms suggesting regional selection. Future research into the less-studied world of other great ape specific bacterial pathogens would help add to the understanding of this receptor family.
Audrey Tjahjadi
Link to original article: https://www.cell.com/current-biology/pdfExtended/S0960-9822(19)30087-9
No comments:
Post a Comment