Evidence from the Drosophilia genome suggest that they are undergoing purifying selection. In the article Sella et al. use genomic data from the different Drosophila species, including D. melanogaster and D. simulans, D. virilis, D. americana, D. miranda and D. pseudoobscura. The genome encodes the heritable phenotype of an organism so patterns of variation within and between species can provide answers to these questions, as well as help characterize the intensity and rate of adaptation. Numerous studies have estimated that 40–50% of the amino acid substitutions in Drosophila species are adaptive but they are not clustered in particular subsets of genes. Estimates indicate that Drosophila species experience an adaptive amino acid substitution every 200–400 generations and one in non coding regions at potentially more than five times that rate. In the end Sella et al. determined that most of the genome is under purifying selection and a large fraction of divergence at amino acid, and non coding regions, is beneficial. As well as the dynamics of neutral and weakly selected alleles are affected substantially by selection at linked sites.
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000495
Potluck Post- 4/13/2020
Annelise Beer
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