In this article, Song et al. analyzed the role of Hox genes, known to play critical roles during early development, in the adult skeleton. Specifically, they examined the role of the Hox11 gene by generating a Hox11 conditional allele that was able to be completely deleted at any stage of development. Hox11 is involved in regulating development of limb bones such as the tibia and radius and it was previously unknown whether it played a role past embryonic development. This study found that post-natal and adult expression of Hox11 is needed to allow for the process of replacing rapid growth woven bone grown during embryogenesis with stronger lamellar bone, showing that this Hox gene is required for maintenance of the adult skeleton.
Audrey Tjahjadi
Link to original article: https://www.pnas.org/content/117/13/7296/tab-figures-data
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