Schizophrenia (SZC) is a psychiatric disorder that varies in clinical presentations. Disorder presentations include delusions, hallucinations, disorganized speech, negative behavior and loss of emotion or interest. The authors approach their research question from the manner that while SCZ is extremely heterogenous, differential expression analysis have only been derived from homogenous populations. Therefore, it is not helpful in detecting expression differences between samples. The authors tested for the “equality of variances” to normalize expression data from the brains of 212 SCZ patients and 214 brains from an unaffected control sample. Results shows that VEGFA (vascular endothelial growth factor), BDNF (brain-derived neurotrophic factor) and 85 other genes showed a significantly higher expression variance among SCZ samples than in control sample. It is noted that one gene actually showed an inverse relationship. This analysis was extended to gene sets and was tested in what is called a “Mahalanobis distance-based test” for multivariate homogeneity of group dispersion. It was determined that over 110 gene sets, encoded for several difference complexes that were in charge of cerebellar cortex morphogenesis, neuromuscular unction development and the cerebella Purkinje cell layer showed a higher expression variability.
Gene set, cerebellar cortex morphogenesis, show more dispersed expression in SCZ.
Gene set, cerebellar cortex morphogenesis, show more dispersed expression in SCZ.
Warrenkevin Henderson
Nature Journal Update 3/5 03APR20
https://www.nature.com/articles/s41537-020-0097-5
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