Long non-coding RNAs are RNA molecules that are not thought to code for proteins. However, lcRNAs are thought to play a role in regulation of gene expression. An earlier study has identified the use of CRISPR to silence lcRNAs to potentially allow for expression of the gene or increased protein production. This article details how a form of CRISPR called CRISPR interference (CRISPRi) can be used to prevent transcription rather than cause a break in the DNA. In particular, this technology could be useful in the treatment of lymphomas.
Audrey Tjahjadi
Link to commentary about article: https://www.pnas.org/content/117/15/8225?etoc=#ref-7
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