By now it is easily accepted and widely known that a variety of factors go into how the actual coding portion of the genome is transcripted and translated into a final protein end product. This article by Shoshani and Cleveland succinctly outlines how one such factor, mRNA stability, can contribute to gene expression. The autoregulation of tubulin is such that the production of more tubulin is regulated by the concentration of tubulin already present (hence, the autoregulation: tubulin regulates its own production). A portion of the tubulin protein (TTC5 in image) binds to a receptor site on the tRNA which causes the mRNA being translated to degrade, maintaining tubulin concentrations. The discovery of exactly how this mechanism functions can lead to new insights on cell biology and cell self-regulation.
Shoshani O, Cleveland DW. Gene expression regulated by RNA stability. Science. 2020 Jan 3;367(6473):29-.
Ryan McRae
Science
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