This is the blog for GW students taking Human Evolutionary Genetics. This site is for posting interesting tidbits on: the patterns and processes of human genetic variation;human origins and migration; molecular adaptations to environment, lifestyle and disease; ancient and forensic DNA analyses; and genealogical reconstructions.

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Thursday, February 6, 2020

The ethics of changing genes in the embryo A. Williams Potluck 2/11/20

Sarah Chan, University of Edinburgh



The author discusses how changes in methods and technology have made it a reality to change genes in human embryos given the success of CRISPR technologies and how this has sparked controversy among scientists and the public on whether or not the use of human embryos should be used in this area of research given the implications. She discusses the public fear after Chinese scientists published an article on their success at editing the human genome in non-viable human embryos. It is reasonable for the public, and other scientists, to be concerned about the use of genome editing in humans given political histories of eugenics and sterilization so it is necessary to not only be aware of these concerns but to put in place systems that stop them from becoming a reality. However, some of the concern is misplaced through misunderstanding of the methodology used and what this technology is being used for.

The author states there is a huge difference between non-viable, edited embryos being used for research and edited genomes being implanted for reproduction. Babies with edited genomes have already been born, and there are even more who have had their genome sequenced before being implanted to ensure their genetics do not contain life-threatening alterations. She states that this field is all about weighing the risks. What are the risks of not pursuing research in a method that could improve the health and lifespan of individuals? What are the risks of pursing this research without proper checks?

As someone who has always been pro-choice I have not been concerned with the use of human embryos in scientific research. However, I think it is irresponsible to ignore the risks and implications of what this field could turn into if not properly considered ethically with the necessary checks and think we need to stay informed about these issues as the years go on. Is there a point where female choice and individual health could compromise human rights? On the other hand, is there a point where human rights could compromise human health and female choice?


https://www.eurostemcell.org/ethics-changing-genes-embryo

-Alexis W.

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