Manjusha Vaidya and Kiminobu Sugaya published a paper in PLOS ONE on Feb 24th that describes a gene that they have linked to cancers such as breast cancer. SOX2 is a gene that is highly expressed in cancer stem cells and can be used to understand cancer formation, progression, and metastasis. They hypothesized that these embryonic stem cell gene expressions made CSCs more resistant to conventional chemo and radiation therapies. But the occurrence of a cancer susceptibility related SOX2-SNP in genomic, cytoplasmic as well as exosomal DNA might be valuable as a general cancer susceptibility marker that is not specifically limited to cancers of breast or gallbladder. Thus the SOX2 gene is an indispensable player in cancer progression and malignancy grade determination giving it great value in patient survival.
Journal Post 2/24/2020
Annelise Beer
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229309
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