Overall, when an individual has a severe mutation in an associated gene, it depends on the biology of the gene, mutation of gene function, and secondary events to determine whether the individual develops schizophrenia. The damaging mutation in the associated gene may not afflict the individual that it appears in first, but rather in later generations.
Kailie Batsche
Potluck for 3 March 2020
Link (paper and image): https://science-sciencemag-org.proxygw.wrlc.org/content/sci/367/6477/569.full.pdf
Authors:
S. Gulsuner, D. J. Stein, E. S. Susser, G. Sibeko, A. Pretorius, T. Walsh, L. Majara,
M. M. Mndini, S. G. Mqulwana, O. A. Ntola, S. Casadei, L. L. Ngqengelele, V. Korchina,
C. van der Merwe, M. Malan, K. M. Fader, M. Feng, E. Willoughby, D. Muzny, A. Baldinger, H. F. Andrews, R. C. Gur, R. A. Gibbs, Z. Zingela, M. Nagdee, R. S. Ramesar, M.-C. King*, J. M. McClellan
M. M. Mndini, S. G. Mqulwana, O. A. Ntola, S. Casadei, L. L. Ngqengelele, V. Korchina,
C. van der Merwe, M. Malan, K. M. Fader, M. Feng, E. Willoughby, D. Muzny, A. Baldinger, H. F. Andrews, R. C. Gur, R. A. Gibbs, Z. Zingela, M. Nagdee, R. S. Ramesar, M.-C. King*, J. M. McClellan