As colon cancer is one of the leading cause of
cancer death in US many research are going on to find treatments for this threatening
disease. Recent discoveries indicate the role played by two specific Hox genes
HOXA4 and HOXA9 in colon cancer development. As we know, Hox genes are involved
in the regulation of stem cells, Dr. Boman and other researchers found that the
over expression of these 2 specific HOX genes resulted in stem cell
overpopulation, hence, colon cancer development. They proposed that decreasing
the expression of these 2 Hox genes could be used as a treatment to prevent the
replication of colorectal cancer stem cells.
Axelle
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