This is the blog for GW students taking Human Evolutionary Genetics. This site is for posting interesting tidbits on: the patterns and processes of human genetic variation;human origins and migration; molecular adaptations to environment, lifestyle and disease; ancient and forensic DNA analyses; and genealogical reconstructions.

GWHEG figure

GWHEG figure

Tuesday, March 6, 2018

HOX genes and chinese cattle


This article published in Gene caught my interest as it relates to the evolution of body size.  The SIX4 gene is critical to muscle regeneration and the early stages of ontogeny.  Transcription factors for it also correlate with body size measurements such as withers (shoulder) height, back fat thickness, chest depth and circumference, and loin area.  While all this is mostly motivated by economic reasons, its ties to overall body size are interesting as well.  This study found 7 SNPs in the promoter region for SIX4 which ultimately lead to 18 transcription factor compositions.  Two of the resulting polymorphisms were correlated with higher fat content and generally larger cattle.  I would be interested to see if these transcription factors correlate to overall body size and/or fat content in primates as well.

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