In this recent study, the researchers use a longitudinal study approach in order to show direct changes in 4857 CpG methylation sites. Among many variables, the researchers looked at methylation before and after 40 patients underwent bariatric surgery and tracked their levels for 12 months afterwards. As their BMI decreased, so did their measure for biological age and epigenetic age acceleration. Of the 4857 CpG sites with methylation changes, 420 were associated with metabolic traits and genes. Two transcription factors were of increased interest due to their correlation with adipocyte development and type 2 diabetes: TCF7L2 and LMO2. The authors stress the clinical importance of these findings and find significant evidence that bariatric surgery will help long term with patients' weight loss and maintenance as well as prevent against metabolic disorders due to the drastic epigenetic changes associated with it.
-Alexis Williams
Fraszczyk et al. Clinical Epigenetics (2020) 12:14
https://doi.org/10.1186/s13148-019-0790-2
https://doi.org/10.1186/s13148-019-0790-2
Photo: https://doi.org/10.1016/j.celrep.2013.03.018
No comments:
Post a Comment