This article posits its research on analyzing whole genome, whole-transcriptome and DNA methylation for tumors represented in prostate cancers from asian populations because most data acquired for prostate cancer is derived from western populations. Yields demonstrate that there is a difference in the distribution of genetic expression of prostate lesions from those that were established by The Cancer Genome Atlas. Chinese patients had genomic alterations that were distinct from Western populations. These patients had 41% of their tumors caused by mutations in FOXA1 and 18% each had deletions in ZNF292 and CHD1. FOXA1 is a pioneer factor that targets the androgen response and has demonstrated its self as having a role in the oncogenesis of prostate cancer. Increase levels of FOXA1 are associated with poor prognosis where decreased level of FOXA1 are predict good prognosis. FOXA1 was the highest mutated gene in Chinese cohorts where as in Western populations it covered the entire coding sequence .
https://www.nature.com/articles/s41586-020-2135-x
Warrenkevin Henderson
Nature Journal Post 1/5
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