Genetic heritability can vary greatly in certain diseases but generally it is believed that there is a strong correlation between genes and ADs. Many examples may give insight as to the beneficial traits of certain AD genes, such as the hemoglobin-ß mutation that causes sickle cell anaemia. Though potentially deadly when homozygous, heterozygous carriers demonstrate negative phenotypic effects while they remain a resistance to malaria. Based on the genetic predispositions for most or all ADs, as more information becomes available on the human genome, it may become clearer as to how these genes persist, and how to create personalised medications to combat the malignant mutations.
GWHEG figure
Monday, September 14, 2015
Genetic Susceptibility to Autoimmune Diseases
It is curious that despite the negative impact of autoimmune diseases on overall human health, they still prevail in up to 9% of the population and appear to be rising. In the Nature Journal, the authors present possible explanations as to how or why natural selection has not weeded out potentially deadly immune responses.
Genetic heritability can vary greatly in certain diseases but generally it is believed that there is a strong correlation between genes and ADs. Many examples may give insight as to the beneficial traits of certain AD genes, such as the hemoglobin-ß mutation that causes sickle cell anaemia. Though potentially deadly when homozygous, heterozygous carriers demonstrate negative phenotypic effects while they remain a resistance to malaria. Based on the genetic predispositions for most or all ADs, as more information becomes available on the human genome, it may become clearer as to how these genes persist, and how to create personalised medications to combat the malignant mutations.
Genetic heritability can vary greatly in certain diseases but generally it is believed that there is a strong correlation between genes and ADs. Many examples may give insight as to the beneficial traits of certain AD genes, such as the hemoglobin-ß mutation that causes sickle cell anaemia. Though potentially deadly when homozygous, heterozygous carriers demonstrate negative phenotypic effects while they remain a resistance to malaria. Based on the genetic predispositions for most or all ADs, as more information becomes available on the human genome, it may become clearer as to how these genes persist, and how to create personalised medications to combat the malignant mutations.
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