This is the blog for GW students taking Human Evolutionary Genetics. This site is for posting interesting tidbits on: the patterns and processes of human genetic variation;human origins and migration; molecular adaptations to environment, lifestyle and disease; ancient and forensic DNA analyses; and genealogical reconstructions.

GWHEG figure

GWHEG figure

Thursday, October 25, 2018

Mouse pups with same-sex parents born in China using stem cells and gene editing


Researchers from the Chinese Academy of Science were able to use haploid ESCs to create healthy viable mice that has DNA from two mothers; however, mice from male parents survived in utero but only lived for 48 hours outside the womb. The process of creating mice from same-sex parents had been done before, but when the mice from two females were born the first time it was tried with out the use of haploid ESCs they were stunted in growth and did not live very long. The mice created from two males did not even survive birth the over grew in utero and didn't survive birth. This discovery does not mean that haploid ESCs to create same sex offspring can be used in all species of mammals that cannot same sex reproduce because each species has different imprinting sites that have to be recognized and deleted to produce viable offspring, but it is a step in identifying all the possibilities of gene editing and stem cells.

original paper:
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30441-7
Science Daily report:
https://www.sciencedaily.com/releases/2018/10/181011143115.htm

Post by Sophia Sanchez

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