This is the blog for GW students taking Human Evolutionary Genetics. This site is for posting interesting tidbits on: the patterns and processes of human genetic variation;human origins and migration; molecular adaptations to environment, lifestyle and disease; ancient and forensic DNA analyses; and genealogical reconstructions.

GWHEG figure

GWHEG figure

Monday, February 2, 2015

Genomic evolution of pregnancy


[Cocktail chatter by Alexandra Arnold]
My cocktail chatter is about how ancient “genetic parasites” spurred evolution o pregnancy in mammals. A group of scientists went with Dr. Vincent Lynch, assistant professor of human genetics at the University of Chicago, to look at the origins of pregnancy in mammals. By characterizing the pregnant uterine transcriptomes, they found that thousands of genes had evolved endometrial expression during the origins of mammalian pregnancy. They found that as development went from a hard eggshell to the soft tissue surrounded by placenta now, that there was a stronger connection between the mother and the developing egg, which had evolved into a stronger and more successful pregnancy, especially with the increase of maternal-fetal communication. They also found many cells to regulate decidualization as well as immune suppression genes to stop the mother’s body from attacking the fetus. I found this article and the additional information to be incredibly interesting. It was really interesting learning about different fetal developments in animals and it was great seeing how it evolved over time from all those years ago. It is amazing seeing what genes can do and how much of an impact they really have.

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